59 startups took the stage at Y Combinator’s Demo Day 2  and among the many highlights have been an organization that helps builders handle in-app subscriptions; a service that allows you to create animojis from actual photographs; and a surplus medical tools reselling platform. Oh… and there was additionally an organization that’s developed a wholly new form of life kind utilizing e coli micro organism. So yeah, that’s taking place.

Based mostly on some investor buzz and what caught TechCrunch’s eye, these are our picks from the second day of Y Combinator’s shows.

Yow will discover the full list of companies that presented on Day 1 here, and our top picks from Day 1 here. 


With a founding crew together with a few of the main luminaries within the area of biologically impressed engineering (together with George Church, Pamela Silver, and Jeffrey Means from Harvard’s Wyss Institute) 64-x is engineering organisms to operate in in any other case inaccessible environments. Chief government Alexis Rovner, herself a post-doctoral fellow on the Wyss Institute, and chief working officer Ryan Gallagher, a former BCG Advisor, want to commercialize analysis from the Institute round accelerating and increasing the flexibility to provide functionalized proteins and sequence-defined polymers with numerous chemistries. Mainly they’ve engineered a brand new life kind that they need to use for novel sorts of bio-manufacturing.

Why we favored it: These geniuses invented a brand new life kind.

CB Therapeutics

Sher Butt, a former lab listing at Steep Hill, noticed that cannabinoids have been as near a miracle treatment for ache, epilepsy and different power circumstances as medication was going to get. However plant-based cannabinoids have been pricey and produced inconsistent outcomes. Alongside Jacob Vogan, Butt realized that biosynthesizing cannabinoids would cut back manufacturing prices by an element of ten and increase manufacturing 24 instances present yields. With a deep expertise commercializing medicine for Novartis and because the founding father of the hashish testing firm, SB Labs, Butt and his technical co-founder are uniquely positioned to deliver this new remedy to market.

Why we favored it: Utilizing manufacturing processes to make industrial portions of what seems like nature’s greatest painkiller at scale just isn’t a foul thought.


RevenueCat founders

RevenueCat helps builders handle their in-app subscriptions. It provides an API that builders can use to assist in-app subscriptions on iOS and Android, which suggests they don’t have to fret about all of the nuances, bugs and updates on every platform.

The API additionally permits builders to deliver all the info about their subscription enterprise collectively in a single place. It may be on to one thing, although it isn’t clear how huge that one thing is sort of but. The nine-month-old firm says it’s at present seeing $350,000 in transaction quantity each month; it’s making some undisclosed share of cash off that quantity.

Read more about RevenueCat here.

Why we favored it: Write code. Launch app. Use RevenueCat. Receives a commission. That seems like a great formulation for a reasonably compelling enterprise.



Indonesia is a rustic in a transition, with a rising class of people with belongings to take a position but who, financially, don’t meet the bar set by many wealth managers. Enter Ajaib, a newly minted startup with the very daring ambition of turning into the “Ant Financial of wealth administration for Indonesia.” Why the comparability? As a result of China was in the identical boat not way back — a  nation whose center class had little entry to wealth administration recommendation. With the founding of Ant Monetary almost 4 years in the past, that modified. Actually, Ant now boasts greater than 400 million customers.

China is dwelling to just about 1.four billion, in contrast with Indonesia, whose inhabitants of 261 million is tiny as compared. Nonetheless, if its plans work out to cost 1.four % for each greenback managed, with an estimated $370 billion in financial savings within the nation to chase after, it may very well be going through a significant alternative in its yard if it good points some momentum.

Why we favored it: If Ajaib’s wealth administration plans (to cost 1.four % for each greenback it manages) work out — and with a complete market of $370 billion in financial savings in Indonesia — the corporate may very well be going through a significant alternative in its yard.



The scooter craze is hitting Latin America and Grin is greasing the wheels. The Mexico Metropolis-based firm was launched by co-founder Sergio Romo after he and his associate realized they weren’t going to have the ability to get a reduce of the massive “birds” on the scooter block within the U.S. (as Axios reported). Romo and his co-founder have already lined up a slew of traders for what will be the hottest new deal in Latin America. Backers embody Sinai Ventures, Liquid2 Ventures, 500 Startups, Monashees and Base10 Companions.

Why we favored it: Scooters are so 2018. However there’s some huge cash to be made in mobility, and because the problem from Hen and Lime to Uber and Lyft in hyperlocal transit has revealed, there’s no dominant participant that’s taken over the market… but.


Creating animated emojis made out of actual photographs, Emojer simply may be essentially the most enjoyable you may have with a digicam. The corporate’s software program makes use of deep studying algorithms to detect physique components and guides customers in creating their very own avatars with only a easy picture take from a cell phone. It’s changing deep Photoshop experience and animation expertise with an excellent easy interface. The avatars look similar to Elf Your self, a well-liked web site that allow you to paste your mates’ faces on dancing Christmas elves that went viral yearly at Christmastime. Founders have PhDs in machine studying and laptop imaginative and prescient.

Why we favored it: As the corporate’s chief government stated, Snap was for sexting, and Fb was scorching or not, so who says the subsequent huge client platform couldn’t be the computer virus of simply generated selfiemojis (akin to Elf Yourself)?

Osh’s Reasonably priced Prescription drugs

Osh’s Affordable Pharmaceuticals is a public profit company connecting docs and sufferers with sources of low-cost, compounded prescription drugs. The corporate is seeking to lower obstacles to entry for medicine for uncommon ailments. Three weeks in the past the corporate launched a drug to deal with Wilson’s Illness. There was no entry to the drug that treats the illness earlier than in Brazil India or Canada. It slashes the price of medicine from $30,000 a month to $120 per 30 days. The corporate estimates it has a complete addressable market of $17 billion. “Generic drug pricing is a disaster, individuals are dying as a result of they’ll’t get entry to the medication they want,” says chief government Alex Oshmyansky. Osh’s might need an answer.

Why we favored it: Promoting lower-cost medicines for uncommon ailments in international locations that beforehand hadn’t had entry to them is an efficient enterprise that’s good for the world.

Medinas Well being

Tackling a $75 billion drawback of healthcare waste Medinas Health is giving hospitals a simple strategy to resell their used and a and provides. The corporate has already raised $1 million for its market to assist healthcare organizations purchase and promote tools. With a seed spherical led by Ashton Kutcher and Man Oseary’s Sound Ventures, and Common Catalyst’s Tough Draft Ventures fund, the corporate can be working to decrease prices for cash-strapped rural well being care facilities.

Why we favored it: Discovering makes use of for hospital tools that’s been mendacity fallow in corners is an enormous enterprise. A $75 billion greenback enterprise if Medinas’ estimates are appropriate. Add serving to reduce prices for rural medical amenities and Medinas is a enterprise we are able to get behind.

And Consolation

Plus-size girls have restricted clothes choices even on the largest retailers like Nordstrom and Macy’s. Whereas a majority of American girls fall into the plus-size clothes class, 100 million girls are constrained to buying a really small share of choices. And Comfort needs to unravel the availability drawback. To do that, the founders, two former Harvard classmates, are constructing a direct-to-consumer style model with fashionable, minimalist choices for plus-size girls, together with tunic shirts and an apron costume. It’s very early days for the model, however since launching in current weeks, they’ve seen $25,000 in gross sales.

Why we favored it: This direct-to-consumer style model is bringing greater high quality, better-designed clothes choices to a market that’s underserved and rising shortly. What’s to not like?



Influencers of the world are uniting on cellular app, ShopWith, which permits customers to browse digital storefronts and aisles alongside their favourite style and sweetness creators and YouTubers. Customers can see precisely what merchandise these influencers have featured and should purchase them with out ever leaving the app. It’s a free obtain and hours of commercially consumptive enjoyable.

It’s just like the QVC mannequin, however for GenZ customers whose shopping for habits are influenced by social video content material on YouTube, Instagram and Snapchat. The corporate revealed that one magnificence influencer made $10,000 inside 5 hours, utilizing the ShopWith platform. The founders are former product managers with expertise constructing social commerce merchandise at Facebook and Amazon.

Why we favored it: The QVC for GenZ not solely has a pleasant ring to it, it’s a recipe for making money registers hum. A mobile-first, influencer-based procuring firm is one thing that we’d positively not name an impulse buy.

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